Dr Samantha Brugmann is an Associate Professor in the Divisions of Plastic Surgery and Developmental Biology at the Cincinnati Children's Hospital Medical Center. Her lab studies craniofacial development and diseases. Specifically, the lab examines the role of primary cilia on tissues that make up the craniofacial complex. Dr. Brugmann uses avian, murine and human induced pluripotent stem cells to examine how cilia transduce various molecular signals important for normal embryonic development. These areas of study serve to inform us on the molecular basis for pathologies associated with ciliopathies.
Dr David Clouthier is a Professor in the Department of Craniofacial Biology at the University of Colorado. His lab studies the molecular and cellular mechanisms driving normal facial and heart morphogenesis. Neural crest cells, originating from the junction of the neural and non-neural ectoderm, give rise to most of the face and portions of the cardiovascular system. Dr Clouthier uses mouse and zebrafish models to dissect the signaling cascades regulating neural crest cell patterning and determine how perturbation of these pathways effect normal embryonic development. This information informs the genetic basis of human birth defect syndromes.
Dr. Jean-Pierre Saint-Jeannet is a Professor and Vice Chair for Research in the Department of Basic Science and Craniofacial Biology at New York University College of Dentistry. His research explores the cellular and molecular mechanisms regulating neural crest and cranial placode progenitors formation in normal and pathological situations, using the frog Xenopus laevis as a model system. Dr. Saint-Jeannet has served on numerous NIH and NSF study sections . He is the editor of a book “Neural Crest Induction and Differentiation” (Springer, 2006), and the guest editor of a recent special issue of genesis “Celebrating 150 Years of Neural Crest Research”.